Synthesis and Biological Activity of Benzoselenazole and Benzo[ b ]Selenophene Analogues: A Review

作者：Jia Li, Jingmin Chen, Jiayao Liu, Xu-Dong Zhou, Yangyang Li, Wei Wang, Wenbing Sheng · 发表于：Drug Development Research · 年份：2025 · DOI：10.1002/ddr.70127 · 被引用次数：4 · 研究领域：Organoselenium and organotellurium chemistry、Sulfur-Based Synthesis Techniques、Free Radicals and Antioxidants

Selenium, an essential micronutrient in the human body, not only exhibits potent antioxidant properties but also plays a critical role in regulating thyroid hormone metabolism, maintaining normal immune function, and inhibiting tumour progression. Among selenium-containing compounds, ebselen is the most extensively studied drug candidate. Research has shown that various derivatives obtained through structural modifications of Ebselen exhibits significant biological activities; however, these compounds have yet to progress to clinical trials. Consequently, selenium-containing heterocyclic compounds represent a promising avenue for drug discovery and development. This review summarizes three synthetic approaches for constructing selenium-containing heterocyclic compounds and emphasizes their notable biological activities and potential applications in pharmaceuticals.