Noninvasive assessment of left ventricular performance using pressure–volume loops, blood propulsion and strain tensors: results from the World Alliance of Societies of Echocardiography study

作者：Gianni Pedrizzetti, Juan Ignacio Cotella, Karima Addetia, G Tonti, Martin Gruca, Jeremy Slivnick, John E. Blair, Federico M. Asch, Victor Mor‐Avi, Roberto M. Lang, the WASE Investigators, Aldo Prado, Ricardo Ronderos, Agatha Kwon, Samantha Hoschke-Edwards, Tânia Regina Afonso, Ana Clara Tude Rodridugues, Babitha Thampinathan, Maala Sooriyakanthan, Wendy Tsang, Mei Zhang, Yingbin Wang, Yu Zhang, Tiangang Zhu, Zhilong Wang, Lixue Yin, Shuang Li, R Alagesan, Sowmya Balasubramanian, R.V.A. Ananth, Vivekanandan Amuthan, Manish Bansal, Ravi R. Kasliwal, Azin Alizadehasl, Anita Sadeghpour, Eduardo Bossone, Davide Di Vece, Rodolfo Citro, Michele Bellino, Tomoko Nakao, Takayuki Kawata, Megumi Hirokawa, Naoko Sawada, Masao Daimon, Yousuke Nabeshima, Masaki Takeuchi, Hye Rim Yun, Seung Woo Park, Ji‐won Hwang, Pedro Gutiérrez Fajardo, Kofo O. Ogunyankin, Edwin S. Tucay, Mark Monaghan, James N. Kirkpatrick, Tatsuya Miyoshi · 发表于：European Heart Journal - Cardiovascular Imaging · 年份：2025 · DOI：10.1093/ehjci/jeaf196 · 被引用次数：5 · 研究领域：Cardiovascular Function and Risk Factors、Elasticity and Material Modeling、Cardiovascular Health and Disease Prevention

AIMS: Left ventricular (LV) pressure-volume (PV) loops, LV strain tensors, and intraventricular pressure gradients (IVPG) provide physiological information on cardiovascular performance and the interaction between LV and arterial system. Given that acquisition of PV loops and IVPG require invasive measurements, there is interest in the development of new noninvasive tools. This work aims to (i) demonstrate the application of noninvasive methods based on three-dimensional echocardiography (3DE) for describing PV loops and haemodynamic performance in terms of IVPG, in conjunction to LV strain tensors and (ii) to determine sex-, age-, and race-related normative values. METHODS AND RESULTS: This work is based on 3DE data from the World Alliance of Societies of Echocardiography study (1403 normal subjects). It applies physics-based techniques to construct noninvasive PV loops, assess blood propulsion using IVPG and 3D deformation using LV strain tensors. Sex- and age-related differences in strain and PV loop are limited to some parameters only, while haemodynamic performance in terms of IVPG does not vary with sex and is reduced with aging. Asian populations are characterized by smaller hearts, higher EF, strain, and PV loop scores than Whites, which in turn have similar LV size to Blacks and higher EF, strain, and PV loop scores, while IVPG was more similar across the populations. CONCLUSION: This study analysed a large normal population with physics-based methods that allow a de...