Characterisation of the respiratory syncytial virus seasonality and its environmental factors in the Americas—a multi-country observational study using routine surveillance networks

作者：Paula Couto, Paula Couto, Harry Campbell, You Li, Marc Rondy, Juliana da Silva Leite, Angel Rodriguez, Andrea Pontoriero, Carlos Maria Giovacchini, Julio Sabido, Mellissa Diaz Musa, Jorge Polanco, Marcelo Ferreira da Costa Gomes, Felipe Cotrim de Carvalho, Liza Lee, Rodrigo A. Fasce, Natalia Alejandra Vergara Mallegas, Paula Camila Rodriguez Ferrari, Paula Rodríguez-Romero, Angélica María Rico Turca, Elias Guilarte García, Ronald Skewes-Ramn, Ruth Gómez Carrera, Ana Del Carmen Sanchez de Molina, Laura Lissette Arévalo Avila, Maria del Mar Ordoñez, Selene Gonzales, Robert Camargo Ángeles, Laura Adriana Flores Cisneros, Irma López Martínez, Catherine Lissette Castillo Castillo, Danilo Franco, Katia Peralta, Cynthia Vazquez de Lopez Moreira, Lidia Redondo Bravo, Priscila Born, Jorge Jara, Paula Couto, Paula Couto, Harry Campbell, You Li, Marc Rondy, Angel Rodriguez, Juliana Leite, Andrea Vicari, Harish Nair, Harish Nair, Andrea Vicari, Harish Nair, Harish Nair · 发表于：The Lancet Regional Health - Americas · 年份：2025 · DOI：10.1016/j.lana.2025.101166 · 被引用次数：8 · 研究领域：Respiratory viral infections research、Virology and Viral Diseases、Animal Virus Infections Studies

Background: Respiratory Syncytial Virus (RSV) is an important cause of bronchiolitis and pneumonia in young children. Circulation patterns represent challenges for immunoprophylaxis, requiring tailored interventions to address RSV activity linked to climate. We assessed RSV seasonality across the Americas and its relation to environmental factors and influenza circulation. Methods: RSV seasonality was assessed using data reported in 2010-2019 to a multi-country respiratory surveillance network. Time-series analysis identified temporal patterns and trends. Negative binomial, Moving Epidemics Method, and WHO Moving Averages Models were compared to assess seasonality. Correlation and regression were used for associations of RSV with environmental and influenza predictors. Findings: During 2010-2019, 32 countries in the Americas reported 14,308,503 respiratory samples, with 446,648 RSV-positive (3.12%) samples. RSV seasonal epidemics progressed from south to north. In South America, RSV seasons began in early May, peaking in August. RSV seasonality was less distinct in Caribbean; RSV started in September and peaked in October-November. Central Americas' RSV season lagged behind influenza, whereas in the Andes, it peaked earlier. At higher latitudes, RSV epidemics occurred earlier with shorter durations. RSV circulation negatively correlated with lower temperatures (-0.43; p < 0.0001), and precipitation (-0.04; p = 0.0035); and was positively correlated with decreased longitude (0...