TFAP2A enhances tumor stemness and promotes metastasis in pancreatic ductal adenocarcinoma

作者：Jiaxin Luo, Zezhi Ding, Dongjie Chen, Yongsheng Jiang, Yizhi Cao, Minmin Shi, Xiaomei Tang, Jia Liu, Meilin Xue, Zehui Zhang, Kexian Li, Yu Bao, Fangfang Ma, Ting Wang, Lingxi Jiang · 发表于：iScience · 年份：2025 · DOI：10.1016/j.isci.2025.113060 · 被引用次数：4 · 研究领域：Peptidase Inhibition and Analysis、Protease and Inhibitor Mechanisms、RNA modifications and cancer

. Mechanistically, TFAP2A could promote epithelial mesenchymal transition (EMT) and recruit macrophage by upregulating MYC, facilitating PDAC cell intravasation. Collectively, these findings unveil molecular mechanisms for PDAC liver metastasis and potential therapeutic targets.