Global burden of atrial fibrillation and atrial flutter due to high alcohol use from 1990 to 2021: estimates from the global burden of disease study 2021

作者：Xiaoming Wang, Changzheng Chen, Zhihua Yang, Yu Chen, Jun Fan, Renchun Tang, Yankun Shi, Lixia Yang · 发表于：BMC Cardiovascular Disorders · 年份：2025 · DOI：10.1186/s12872-025-04947-7 · 被引用次数：5 · 研究领域：Atrial Fibrillation Management and Outcomes、Alcohol Consumption and Health Effects、Cardiovascular Disease and Adiposity

OBJECTIVE: This study comprehensively examines the global burden of atrial fibrillation and atrial flutter (AF/AFL) attributable to high alcohol use from 1990 to 2021, analyzing temporal trends, regional disparities, and sociodemographic determinants using data from the Global Burden of Disease Study 2021 (GBD 2021). METHODS: We extracted GBD 2021 estimates on deaths, disability-adjusted life years (DALYs), and age-standardized rates (ASRs) for AF/AFL due to high alcohol use across 204 countries. Joinpoint analysis and age-period-cohort (APC) modeling were employed to assess temporal trends and disentangle age, period, and cohort effects. RESULTS: In 2021, AF/AFL attributable to high alcohol use contributed to 11,908 deaths (95% UI: 8,860, 14,981) and 362,698 DALYs (95% UI: 263,321, 465,594) globally, marking increases of 176.4% and 132.9%, respectively, since 1990. While age-standardized death rates (ASDR) remained stable (0.2 per 100,000), males bore 2.3-fold higher mortality and 3.7-fold greater DALYs than females. Western Europe had the highest burden (4,589 deaths; 109,934 DALYs), while Oceania reported the lowest (2 deaths; 68 DALYs). High Socio-Demographic Index (SDI) regions exhibited the largest absolute burden, yet low-middle SDI regions experienced the steepest ASDR growth (estimated annual percentage change (EAPC) of ASDR is 2.01%). APC models revealed diverging sex-specific trends: male mortality marginally increased (net drift = 0.091%/year) versus significant f...