Association between cardiometabolic index and coronary artery calcification in young and middle-aged adults with coronary heart disease

作者：Xi Wu, Mingxing Wu, Haobo Huang, Zhe Liu, He Huang, Lei Wang · 发表于：BMC Cardiovascular Disorders · 年份：2025 · DOI：10.1186/s12872-025-04950-y · 被引用次数：8 · 研究领域：Cardiovascular Disease and Adiposity、Diabetes, Cardiovascular Risks, and Lipoproteins、Cardiovascular Function and Risk Factors

BACKGROUND: Coronary artery calcification (CAC) serves as a well-established indicator of subclinical atherosclerosis and is a robust predictor of future cardiovascular complications. The cardiometabolic index (CMI), a recently proposed composite metric combining waist-to-height ratio (WHtR) and the triglyceride-to-HDL cholesterol (TG/HDL-C) ratio, has gained attention as a proxy for both visceral fat accumulation and atherogenic dyslipidemia. Nevertheless, the relationship between CMI and CAC in young and middle-aged individuals diagnosed with coronary heart disease (CHD) remains insufficiently explored. METHODS: This retrospective analysis included CHD patients aged 18-59 years who were admitted to the hospital and underwent coronary computed tomography angiography (CTA) between January 2018 and August 2022. Based on CTA findings, participants were stratified into CAC-positive and CAC-negative groups. Data on demographics, clinical characteristics, and biochemical parameters were obtained. CMI was computed using the formula WHtR × (TG/HDL-C). Multivariate logistic regression models and receiver operating characteristic (ROC) curve analysis were employed to assess both the association and diagnostic value of CMI for CAC. RESULTS: A total of 439 patients were analyzed, of whom 128 were classified as having CAC. The CAC group exhibited a significantly elevated CMI compared to their counterparts without CAC (P < 0.001). After adjusting for potential confounders, CMI emerged as ...