Micronutrients Associated With Anemia in School-age Children and Adolescents 2005–2018: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) Project

作者：Rochelle Werner, Hanqi Luo, Lei Liu, Yuqing Wang, Jiaxi Geng, Yi‐An Ko, Parminder S. Suchdev, O. Yaw Addo, Zulfiqar A Bhutta, Victor J Temple, Frank T. Wieringa, Fabian Rohner, María J Ramírez-Luzuriaga, Reina Engle‐Stone, Anne Williams, Melissa Young · 发表于：Current Developments in Nutrition · 年份：2025 · DOI：10.1016/j.cdnut.2025.107502 · 被引用次数：3 · 研究领域：Iron Metabolism and Disorders、Trace Elements in Health、Folate and B Vitamins Research

BACKGROUND School-age children and adolescents may be at risk for anemia through demands on micronutrients required for growth and maturation. OBJECTIVE This multi-country analysis examined the burden of anemia in children 5-19 y by sex and age category and associations with micronutrient deficiencies, inflammation, and BMI. METHODS Children 5-19 y from surveys in the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) Project were included with hemoglobin, at least one micronutrient (iron, vitamin A, folate, vitamin B 12 , or zinc) and inflammation biomarker, and n >100 per survey. Factors with bivariate relationships with anemia ( P < 0.1) were included in multivariable modified Poisson regression models to examine the attributable burden of anemia. RESULTS This analysis included 54,534 children from 17 surveys in 16 countries (16 surveys for 15-19 y; 9 surveys for 10-14 y; 8 surveys for 5-9 y). Median overall anemia prevalence was 16% (range: 5% in Ecuador, UK, and US to 59% in Côte d'Ivoire) with the highest burden in 15-19 y females (24%). In most surveys, anemia prevalence did not differ by sex for children 5-14 y, and median anemia prevalence was lower in children 10-14 y (7%) than 5-9 y (9%) or 15-19 y (22%). In most surveys, higher anemia prevalence was associated ( P < 0.05) with iron deficiency (15%) (Prevalence Ratios [PR] 1.6-14.2: 5-9 y, 4-of-7 surveys; 10-14 y, 6-of-6 surveys; 15-19 y, 13-of-14 surveys), vitamin A deficiency (2%) ...