Inferring the landscapes of mutation and recombination in the common marmoset ( Callithrix jacchus ) in the presence of twinning and hematopoietic chimerism

作者：Vivak Soni, Cyril J. Versoza, Jeffrey D. Jensen, Susanne P. Pfeifer · 发表于：bioRxiv (Cold Spring Harbor Laboratory) · 年份：2025 · DOI：10.1101/2025.07.01.662565 · 被引用次数：13 · 研究领域：Evolution and Genetic Dynamics、Animal Behavior and Reproduction、Primate Behavior and Ecology

ABSTRACT The common marmoset ( Callithrix jacchus ) is an important model in biomedical and clinical research, particularly for the study of age-related, neurodegenerative, and neurodevelopmental disorders (due to their biological similarities with humans), infectious disease (due to their susceptibility to a variety of pathogens), as well as developmental biology (due to their short gestation period relative to many other primates). Yet, while being one of the most commonly used non-human primate models for research, the population genomics of the common marmoset remains relatively poorly characterized, despite the critical importance of this knowledge in many areas of research including genome-wide association studies, models of polygenic risk scores, and scans for the targets of selection. This neglect owes, at least in part, to two biological peculiarities related to the reproductive mode of the species — frequent twinning and sibling chimerism — which are likely to affect standard population genetic approaches relying on assumptions underlying the Wright-Fisher model. Using high-quality population genomic data, we here infer the rates and landscapes of mutation and recombination — two fundamental processes dictating the levels and patterns of genetic variability — in the presence of these biological features, and discuss our findings in light of recent work in primates. Our results suggest that, while the species exhibits relatively low neutral mutation rates, rates of r...