Manipulating Liquid‐Liquid Interphase Solute Diffusion for the Construction of Non‐Symmetric Metal‐Quinone Network Nanoarchitectonics and Nano‐Motorization

作者：Wenzhe Xu, Yingke Xue, Yang Chen, Ruixu Yang, Shuwei Liu, Yi Liu, Hao Zhang · 发表于：Advanced Science · 年份：2025 · DOI：10.1002/advs.202503164 · 被引用次数：2 · 研究领域：Micro and Nano Robotics、Gold and Silver Nanoparticles Synthesis and Applications、Nanoplatforms for cancer theranostics

Non-symmetric nanoarchitectonics have demonstrated superior performance in nanotherapeutics compared to their symmetric counterparts, particularly in the design of self-propelled nanodrug delivery systems. However, achieving precise morphological control of non-symmetric nanoarchitectonics composed of molecular drugs, without the use of templates and surfactants, remains a significant challenge. In this work, a strategy is presented to construct non-symmetric metal-quinone network (MQN) nanoarchitectonics with controlled morphology and size by manipulating solute and solvent diffusion behaviors during the nanoprecipitation process. The findings reveal that solute diffusion at the liquid-liquid interface of miscible solvent and antisolvent can be confined by self-generated MQNs, which in turn dictates the morphology of the resulting nanoarchitectonics. By regulating interphase solute diffusion kinetics, a variety of MQN nanoarchitectonics are successfully produced with spherical, semifootball-like, and bowl-like morphologies, ranging in sizes from tens to hundred of nanometers. Notably, the non-symmetric MQN nanobowls are further employed to create self-propelled nanodrugs, which indicates enhanced efficacy in tumor therapy. This study underscores the critical role of liquid-liquid interphase solute diffusion in determining the morphology and size of MQN nanoarchitectonics and highlights the potential of nanoprecipitation as a powerful technique for the precise fabrication of ...