Photoinduced Three-Component 1,2-Dicarbofunctionalization of Unactivated Alkenes via Polarity-Matched Control

作者：Panyi Huang, Ting He, Xinyu Li, Bin Sun, Yongmin Ma · 发表于：Organic Letters · 年份：2025 · DOI：10.1021/acs.orglett.5c02518 · 被引用次数：9 · 研究领域：Radical Photochemical Reactions、Sulfur-Based Synthesis Techniques、Catalytic C–H Functionalization Methods

We herein present a polarity-matched, light-induced radical strategy that enables the direct 1,2-heteroarylalkylation of alkenes using a range of commercially available alkyl bromides and heteroarenes under catalyst- and additive-free conditions. This transformation proceeds under mild reaction conditions, exhibits excellent chemoselectivity, and demonstrates a broad substrate scope (42 examples), including derivatives of pharmaceuticals and natural products.