Effects of rumen-protected choline supplementation on lactation performance of dairy cows: A systematic review and dose-response meta-analysis

作者：Mohtasham Ghaffari, M. R. Rezaei Ahvanooei, Ali Hossein Piray, J Bahrampour, Tao Ma, B.J. Bradford · 发表于：Journal of Dairy Science · 年份：2025 · DOI：10.3168/jds.2024-25844 · 被引用次数：5 · 研究领域：Reproductive Physiology in Livestock、Ruminant Nutrition and Digestive Physiology、Genetic and phenotypic traits in livestock

Peripartum supplementation of rumen-protected choline has been shown to improve cow health and milk production by improving liver function through a reduction in hepatic lipidosis. However, the optimal dose range remains undetermined. To evaluate the effects of supplemented choline chloride on lactation performance and health of dairy cows, a systematic review and dose-response meta-analysis were conducted. This meta-analysis followed the preferred reporting items for systematic reviews and meta-analyses guidelines and used the population (dairy cows), intervention (choline supplementation), comparison (control group vs. choline supplementation), and outcome framework to select studies on dairy cows supplemented with choline. A total of 30 studies from 19 articles and 1 dissertation, identified through Web of Science, Scopus, Google Scholar, and PubMed, were included. The analysis focused on DMI, milk yield and composition, BW, and BCS. Study quality and risk of bias were evaluated using systematic review center for laboratory animal experimentation's risk of bias tool. A 1-stage random-effects meta-analysis with a restricted cubic spline model was employed to assess dose-response relationships, with REML used for variance estimation. Subgroup and sensitivity analyses were performed to address heterogeneity and robustness, and publication bias was assessed using funnel plots and adjusted with the trim-and-fill method. This meta-analysis showed the significant effects of choli...