Near-infrared light and magnetic field dual-responsive 3D printed scaffolds for sequential treatment of infected bone defects

作者：Dapeng Zeng, Hao Wang, Zehao Yu, Xiaohan Mei, Boda Ying, Si Pu, Shibo Liu, Xiangjun Pan, Shicheng Zhou, Ruiyan Li, Yanguo Qin · 发表于：Biofabrication · 年份：2025 · DOI：10.1088/1758-5090/adebb3 · 被引用次数：8 · 研究领域：Medical and Biological Ozone Research、Mesenchymal stem cell research、Periodontal Regeneration and Treatments

Abstract The treatment of infected bone defects remains a challenge due to the complex biological processes involved, including antibacterial, anti-inflammatory, angiogenesis and bone regeneration. Polyetherimide (PEI) has promising applications in orthopaedics, but its biological inertness limits its clinical efficacy. In this study, a smart near-infrared (NIR) light and magnetic field responsive 3D printed scaffold was developed by combining PEI and Fe 3 O 4 nanoparticles. Gelatin methacrylate hydrogel containing aloe-emodin (AE), a natural antimicrobial and antioxidant compound, was subsequently injected into the 3D printed scaffold to create the P–Fe 3 O 4 @GM–AE composite scaffold. This composite scaffold exhibited several key functionalities: Firstly, it effectively eliminated methicillin-resistant Staphylococcus aureus when exposed to NIR light, achieving an in vivo antimicrobial rate of 99.97 ± 0.1%. Secondly, it effectively removed reactive oxygen species and prevented the pro-inflammatory M1 polarization of macrophages in the infected bone defect microenvironment, creating favorable conditions for bone reconstruction. Moreover, during the reconstruction stage, the magnetic composite scaffold, when combined with a static magnetic field, promoted osteogenesis–angiogenesis coupling, thereby accelerating bone repair. Thus, this study provides new insights and methods for the sequential treatment of infected bone defects.