Prevalence of Hepatic Steatosis and Fibrosis in Asian Indian Individuals with Type 2 Diabetes

作者：Khandhulwa Chandramouli Bhuvanesswar, Brijendra Kumar Srivastava, Anandakumar Amutha, V. Damle, Aswin Krishna, Prasanna Kumar Gupta, Phillips Routray, Dhanasekaran Killivalavan, Saravanan Jebarani, Ulagamathesan Venkatesan, Rosette J. Chakkalakal, S. Shalimar, Janardanan Subramonia Kumar, D. Nageshwar Reddy, Anand V. Kulkarni, Ranjit Unnikrishnan, Ranjit Mohan Anjana, Krishna G. Seshadri, Viswanathan Mohan · 发表于：Diabetes Therapy · 年份：2025 · DOI：10.1007/s13300-025-01764-1 · 被引用次数：8 · 研究领域：Liver Disease Diagnosis and Treatment、Diabetes, Cardiovascular Risks, and Lipoproteins、Nutrition and Health in Aging

Metabolic dysfunction-associated steatotic liver disease (MASLD) is closely associated with diabetes mellitus, representing a significant health concern owing to its potential progression to cirrhosis of the liver. We aim to determine the prevalence of MASLD using transient elastography (TE by FibroScan R by Echosens, Paris) in individuals with type 2 diabetes (T2D). The retrospective data (between 2020 and 2024) of 1070 individuals with T2D (who reported no alcohol intake) who underwent FibroScan assessment at two diabetes clinics were included for analysis. Steatosis was classified using controlled attenuation parameters (CAP) (dB/m) as: S0 (< 238 dB/m), S1 (238–260 dB/m), S2 (260–290 dB/m), and S3 (290–400 dB/m). Liver stiffness measurement (LSM)(kPa) was graded as: F0–F1 (no significant fibrosis, ≤ 8.1 kPa), F2 (≥ 8.2–9.6 kPa), F3 (≥ 9.7–13.5 kPa), and F4 (≥ 13.6 kPa). Fibrosis 4 score (FIB-4), nonalcoholic fatty liver disease (NAFLD) fibrosis score (NFS), and aspartate transaminase (AST)-to-platelet ratio index (APRI) were calculated for LSM. The mean age, duration of diabetes, and body mass index (BMI) were 55.1 ± 11.5 yrs, 11.8 ± 8.6 years, and 27.9 ± 4.8 kg/m 2 , respectively. S0, S1, S2, and S3 steatosis were present in 24.4%, 16.0%, 20.1%, and 39.5%, respectively. Fibrosis was absent (F0–F1) in 71.4%, while F2 was present in 9.9%, F3 in 9.3%, and F4 in 9.4%. Any degree of steatosis and fibrosis were present in 75.6% and 28.6%, respectively, and were more frequently ...