Phthalates and bisphenols early-life exposure, and childhood allergic conditions: a pooled analysis of cohort studies

作者：Thomas Boissiere-O’Neill, Nina Lazarevic, Peter D. Sly, Anne‐Louise Ponsonby, Aimin Chen, Meghan B. Azad, Joseph M. Braun, Jeffrey R. Brook, David Burgner, Bruce P. Lanphear, Theo J. Moraes, Richard Saffery, Padmaja Subbarao, Stuart E. Turvey, Kimberly Yolton, CHILD investigator group, Elinor Simons, Piushkumar J. Mandhane, BIS investigator group, Peter Vuillermin, Mimi L. K. Tang, Fiona Collier, Leonard Harrison, Sarath Ranganathan, Toby Mansell, Martin O’Hely, Lawrence Gray, Dwan Vilcins · 发表于：Journal of Exposure Science & Environmental Epidemiology · 年份：2025 · DOI：10.1038/s41370-025-00790-2 · 被引用次数：9 · 研究领域：Effects and risks of endocrine disrupting chemicals、Health, Environment, Cognitive Aging、Microplastics and Plastic Pollution

BACKGROUND: Exposure to plastic additives, such as phthalates and bisphenols, has been associated with a higher risk of allergic conditions, but the evidence is inconsistent for children younger than five. OBJECTIVE: To examine the association between pre- and postnatal urinary phthalates and bisphenols, and allergic conditions, and potential effect modification by sex, in pre-school children, through a pooled analysis. METHODS: We pooled data from the Barwon Infant Study (Australia), the Canadian Healthy Infant Longitudinal Development Study (Canada), the Health Outcomes and Measures of the Environment (United States) and the Environmental Influences on Child Health Outcomes-wide cohorts (United States). Urinary phthalates and bisphenols were measured during pregnancy and early childhood. We estimated daily intakes from urinary concentrations, except for mono-(3-carboxypropyl) phthalate (MCPP). Outcomes, including asthma, wheeze, eczema, and rhinitis, were assessed up to five years of age through questionnaires and clinical assessments. We used generalised estimating equations for single compounds and quantile G-computation for the chemical mixtures. RESULTS: 5306 children were included. A two-fold increase in prenatal dibutyl phthalates (DBP; risk ratio [RR] = 1.08; 95% confidence interval [CI]: 1.00-1.16) and benzyl butyl phthalate (BBzP; RR = 1.06; 95%CI: 1.00-1.12) increased the risk of asthma in children under five. Prenatal MCPP levels were associated with rhinitis (RR...