Association Between Hemoglobin, Albumin, Lymphocyte, and Platelet Score and Diabetic Foot Ulcer: A Cross-Sectional Study

作者：Zhaojie Li, Hui Guo, Zhihong Fu, Dongxiao Li, Yunhui Zhang, Ruizheng Zhu, Junde Wu, Zhaojun Chen · 发表于：The International Journal of Lower Extremity Wounds · 年份：2025 · DOI：10.1177/15347346251355578 · 被引用次数：4 · 研究领域：Diabetic Foot Ulcer Assessment and Management、Inflammatory Biomarkers in Disease Prognosis、Adipokines, Inflammation, and Metabolic Diseases

BackgroundDiabetic foot ulcer (DFU) is a common and serious complication of diabetes mellitus, with high rates of disability and mortality. Early diagnosis and prevention can effectively reduce its incidence. The relationship between hemoglobin, albumin, lymphocyte count, and platelet (HALP) score, which are biomarkers reflecting the inflammatory and nutritional status of the body, and DFU has not been investigated. This study aimed to investigate the association between HALP score and DFU.MethodsThis cross-sectional study used data from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2004. Logistic regression models assessed the relationship between HALP scores (as both continuous and categorical variables) and DFU, adjusting for confounders. Restricted cubic spline (RCS) analysis was employed to evaluate potential non-linear relationships. Subgroup and sensitivity analyses were conducted to ensure the robustness of the findings.ResultsA total of 1604 participants (mean age: 61.67 ± 11.88 years; 52.9% male) were included. Multivariate logistic regression analysis, after adjusting for multiple confounders, revealed a negative correlation between the HALP score and DFU (OR = 0.98, 95% CI: 0.97-0.99, P = 0.041). This association remained significant when the HALP was categorized into quartiles. RCS analysis identified a non-linear relationship, with an inflection point at 44.98 (non-linear P = 0.017). Subgroup analyses confirmed the consistency of the...