Influence of age on the association of vascular risk factors with acute stroke (INTERSTROKE): a case–control study

作者：Catriona Reddin, Graeme J. Hankey, John Ferguson, Peter Langhorne, Shahram Oveisgharan, Michelle Canavan, Helle K. Iversen, Annika Rosengren, Danuta Ryglewicz, Anna Członkowska, Xingyu Wang, Fernando Laņas, Albertino Damasceno, Denis Xavier, Patricio López‐Jaramillo, Andrew Smyth, Salim Yusuf, Martin O’Donnell · 发表于：The Lancet Healthy Longevity · 年份：2025 · DOI：10.1016/j.lanhl.2025.100709 · 被引用次数：7 · 研究领域：Acute Ischemic Stroke Management、Health Promotion and Cardiovascular Prevention、Cardiovascular Health and Disease Prevention

Background The absolute burden of stroke is increasing due to an ageing population, as well as an increased incidence of stroke in young adults. We aimed to determine whether age modifies the magnitude of association between vascular risk factors and stroke in the INTERSTROKE study. Methods INTERSTROKE is an international case–control study of risk factors for first acute stroke. Cases and controls (matched by age and sex) were recruited in 32 countries (between Jan 11, 2007, and Aug 8, 2015). Participants completed a clinical assessment and provided blood and urine samples within 72 h of recruitment. Odds ratios (ORs) for vascular risk factors and their population attributable fractions (PAFs) were calculated among age groups. We tested for an interaction of age by each risk factor. Findings Among 26 950 participants, the mean age of cases was 62·2 years (SD 13·6) and of controls 61·3 years (13·3). Increasing age was associated with a significant increased prevalence for seven vascular risk factors (hypertension, physical inactivity, diabetes, atrial fibrillation, high waist-to-hip ratio, high apolipoprotein B concentration [p<0·0001 for all], and obesity [p=0·016]), reduced prevalence for four vascular risk factors (smoking, alcohol use, psychosocial stress [p<0·0001 for all], and unhealthy diet [p=0·0081]) and unchanged prevalence for one vascular risk factor (depression). Increasing age was associated with a reduced magnitude of OR of stroke for hypertension (p interactio...