Burden and severity of respiratory syncytial virus infection in adults with cardiovascular diseases: A systematic literature review

作者：Yolanda Penders, Ann R. Falsey, Deepak L. Bhatt, Michael Böhm, Andrew J.S. Coats, Lauren M.K. Mason, Laura Mora, Pouya Saeedi, Jean-Philippe Michaud, Frithjof Kosfeld, Lauriane Harrington · 发表于：Progress in Cardiovascular Diseases · 年份：2025 · DOI：10.1016/j.pcad.2025.06.010 · 被引用次数：16 · 研究领域：Respiratory viral infections research、Viral Infections and Vectors

Cardiovascular diseases (CVD) are risk factors for severe respiratory syncytial virus (RSV) infection, which in turn increases the risk of cardiovascular complications. The burden of RSV disease among adults with CVD is not yet fully understood and evidence remains to be consolidated through a systematic approach. Covering the publication period from January 1, 2000 to November 28, 2023, this systematic literature review documented RSV disease burden among adults ≥18 years with CVD including heart failure (HF), ischemic heart disease (IHD), and non-specified CVD. Relevant publications were retrieved from databases (PubMed, Embase) and gray literature (conference abstracts) to quantify the prevalence of CVD among RSV-infected adults, and RSV-related hospitalizations, complications, and mortality among adults with CVD. Sixty-two studies were selected for data extraction; most were conducted in the United States and among inpatients. The highest pooled estimates of CVD prevalence were observed among inpatients: 27.5 % (95 % confidence interval: 24.0-31.2) for HF, 22.9 % (17.7-29.0) for IHD, and 44.4 % (38.5-50.5) for non-specified CVD. Adults with CVD were at significantly higher risk of hospitalization following RSV infection compared to those without these comorbidities. Various general, respiratory, and cardiovascular complications attributable to RSV were documented among adults with CVD. RSV-related in-hospital case fatality rates of 7.8-14.8 % (HF), 13.7-20.0 % (IHD), and ...