Biomarkers in Venous Thrombosis: Diagnostic Potential and Limitations

作者：Yijin Chang, Jiahao Lu, Changsheng Chen · 发表于：Biology · 年份：2025 · DOI：10.3390/biology14070800 · 被引用次数：4 · 研究领域：Venous Thromboembolism Diagnosis and Management、Blood Coagulation and Thrombosis Mechanisms、Atrial Fibrillation Management and Outcomes

Venous thromboembolism (VTE), comprising deep vein thrombosis (DVT) and pulmonary embolism (PE), is a life-threatening vascular disorder associated with significant morbidity and mortality. Prompt diagnosis is crucial for preventing fatal complications. Current clinical VTE diagnosis predominantly relies on imaging modalities such as compression ultrasound, computed tomography angiography (CTA), and magnetic resonance imaging (MRI). However, these techniques are resource-intensive, time-consuming, and may expose patients to radiation risks. Consequently, the development of highly sensitive and specific biomarkers is imperative to enhance early detection and guide therapeutic interventions. This review examines established and emerging biomarkers in venous thrombosis, evaluates current challenges, and outlines promising future directions for biomarker research in VTE.