Association between periodontitis and blood lipid levels: a cross-sectional study

作者：Feiya Zhao, Wei Hu, Yunhong Wu, Yude Ding, Fan Yang · 发表于：BMC Oral Health · 年份：2025 · DOI：10.1186/s12903-025-06341-3 · 被引用次数：8 · 研究领域：Oral microbiology and periodontitis research、Salivary Gland Disorders and Functions、Bone and Dental Protein Studies

BACKGROUND: Dyslipidemia has been implicated as a risk factor for periodontitis; however, the underlying mechanisms remain poorly understood. This study aims to investigate the correlation between blood lipid levels and periodontitis and to explore the cellular and molecular mechanisms linking dyslipidemia to periodontal disease. METHODS: Participants with complete data on serum lipid levels and periodontal examinations were selected from the 2009-2014 National Health and Nutrition Examination Survey (NHANES). Subgroup and logistic regression analyses were performed to assess the associations between periodontal status and lipid profiles, including triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and remnant cholesterol (RC). Single-cell Ribonucleic Acid (RNA) sequencing (scRNA-seq) statistical analysis, cellular metabolic pathway analysis, and CellChat were employed to examine cellular variations and intercellular communication in periodontal tissues with and without periodontitis. RESULTS: A total of 5,342 participants were included in the analysis. Subgroup analyses revealed significant positive associations between elevated levels of TG, TC, and LDL-C and the prevalence of severe periodontitis. Participants in the high TC group had a 55% higher risk of severe periodontitis compared to those in the normal TC group (OR = 1.55, 95% CI: 1.17-2.05). Similarly, the risk of severe periodontitis...