Exploring perceptions and preferences for PrEP choice and of an mHealth intervention: insights from the ImPrEP CAB‐Brasil study

作者：Cristina Pimenta, Claudio Gruber Mann, Brenda Hoagland, Eduardo Carvalheira, Cristina Moreira Jalil, Marcos Benedetti, Nilo Martinez Fernandes, Carolina Coutinho, Emilia M. Jalil, Mayara Secco Torres Silva, Roberta Trefiglio, Alessandro Farias, Maria Paula Gomes Mourão, José Valdez Madruga, Josué Nazareno de Lima, Ronaldo Zonta, Gabrielle O’Malley, Valdiléa G. Veloso, Beatriz Grinsztejn, Thiago S. Torres, for the ImPrEP CAB‐Brasil Study · 发表于：Journal of the International AIDS Society · 年份：2025 · DOI：10.1002/jia2.26493 · 被引用次数：7 · 研究领域：HIV/AIDS Research and Interventions、HIV, Drug Use, Sexual Risk、Travel-related health issues

INTRODUCTION: Although the efficacy of long-acting injectable cabotegravir (CAB-LA) for pre-exposure prophylaxis (PrEP) is well-known from clinical trials, research is needed to guide effective strategies for its implementation. We describe a qualitative study to assess perceptions and preferences for PrEP choice and acceptability of an mHealth intervention within the ImPrEP CAB Brasil study. METHODS: ImPrEP CAB Brasil is an implementation study of same-day delivery of CAB-LA for young sexual and gender minorities (SGM; 18-30 years) in oral PrEP public health clinics in six Brazilian cities. At enrolment, participants received counselling on HIV prevention (SOC) or SOC+mHealth tool to choose between oral or injectable PrEP. The mHealth tool consisted of five videos describing HIV combined prevention including PrEP options. A subset of participants from each site were invited to participate in the qualitative study (October 2023-July 2024). Semi-structured interviews were conducted, recorded and transcribed. Data were fed into ATLAS.ti.24 software. Conventional content analysis was used for coding categories based on an inductive reasoning process. RESULTS: We conducted 120 interviews (48 SOC and 72 SOC+mHealth; 107 CAB-LA and 13 oral PrEP). Participants reported not knowing about CAB-LA before enrolment; some recently heard from a partner or friend. Reasons for choosing CAB-LA were perceived convenience, practicality, easier adherence to bimonthly injections and higher effica...