Cognition–Eye–Brain Connection in Alzheimer's Disease Spectrum Revealed by Multimodal Imaging

作者：Yan Shi, Tingting Shen, Su Yan, Jianwen Liang, Tianyunxi Wei, Yijin Huang, Rong Gao, Ning Zheng, Renpuchi Ci, Min Zhang, Xiaoying Tang, Yuanyuan Qin, Wenzhen Zhu · 发表于：Journal of Magnetic Resonance Imaging · 年份：2025 · DOI：10.1002/jmri.70003 · 被引用次数：4 · 研究领域：Glaucoma and retinal disorders、Dementia and Cognitive Impairment Research、Retinal Imaging and Analysis

BACKGROUND: The connection between cognition, eye, and brain remains inconclusive in Alzheimer's disease (AD) spectrum disorders. PURPOSE: To explore the relationship between cognitive function, retinal biometrics, and brain alterations in the AD spectrum. STUDY TYPE: Prospective. SUBJECTS: Healthy control (HC) (n = 16), subjective cognitive decline (SCD) (n = 35), mild cognitive impairment (MCI) (n = 18), and AD group (n = 7). FIELD STRENGTH/SEQUENCE: 3-T, 3D T1-weighted Brain Volume (BRAVO) and resting-state functional MRI (fMRI). ASSESSMENT: In all subgroups, cortical thickness was measured from BRAVO and segmented using the Desikan-Killiany-Tourville (DKT) atlas. The fractional amplitude of low-frequency fluctuations (FALFF) and regional homogeneity (ReHo) were measured in fMRI using voxel-based analysis. The eye was imaged by optical coherence tomography angiography (OCTA), with the deep learning model FARGO segmenting the foveal avascular zone (FAZ) and retinal vessels. FAZ area and perimeter, retinal blood vessels curvature (RBVC), thicknesses of the retinal nerve fiber layer (RNFL) and ganglion cell layer-inner plexiform layer (GCL-IPL) were calculated. Cognition-eye-brain associations were compared across the HC group and each AD spectrum stage using multivariable linear regression. STATISTICAL TESTS: Multivariable linear regression analysis. Statistical significance was set at p < 0.05 with FWE correction for fMRI and p < 1/62 (Bonferroni-corrected) for structural a...