Construction of Lymphoma Organoids and Applications in Tumor Microenvironment Research

作者：Miao Zhu, Tiantian Li, Sen Han, Dongyi Zhao, Xueqing Chen, Vera Wong, Haibo Wang, Yanqing Liu · 发表于：European Journal Of Haematology · 年份：2025 · DOI：10.1111/ejh.14448 · 被引用次数：3 · 研究领域：CAR-T cell therapy research、Monoclonal and Polyclonal Antibodies Research、Cancer Cells and Metastasis

Lymphoma is a class of malignant tumors originating from the lymphatic system, with a complex tumor microenvironment playing a critical role in tumor initiation, progression, and therapeutic response. In recent years, the rapid development of organoid technology has provided a novel platform for lymphoma research, enabling effective in vitro simulation of the lymphoma microenvironment. Although methods for establishing lymphoma organoids have gradually matured and related studies are increasing, challenges such as the lack of standardized protocols and incomplete microenvironment reconstruction remain. This review aims to summarize the techniques, characteristics, and applications of lymphoma organoids in tumor microenvironment research, exploring their potential in immunotherapy and disease mechanism studies. It seeks to offer new insights and directions for future lymphoma research.