Prognostic role of preoperative inflammatory markers in postoperative lung metastasis of colorectal cancer: a retrospective study

作者：Jiukang Sun, Weili Xiong, Fang Zhang, C. Song · 发表于：BMC Gastroenterology · 年份：2025 · DOI：10.1186/s12876-025-04091-8 · 被引用次数：8 · 研究领域：Inflammatory Biomarkers in Disease Prognosis、Immune cells in cancer、Colorectal Cancer Surgical Treatments

BACKGROUND: This study aims to investigate the predictive significance of inflammatory markers for postoperative lung metastasis in colorectal cancer (CRC) patients. The focus is on exploring the relationship between traditional inflammatory markers, such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and newly introduced indices like C-reactive protein (CRP)-albumin-lymphocyte (CALLY), and their association with CRC progression and lung metastasis. METHODS: A retrospective review of medical records from 303 CRC patients at the First Affiliated Hospital of Nanjing Medical University (January 2014 to December 2023) was conducted. Various inflammatory markers, baseline characteristics, and survival data were analyzed. Statistical analyses, including univariate and multivariate Cox regression and logistic regression, were performed to determine associations between inflammatory factors and CRC outcomes. RESULTS: Among the patients, 55 developed lung metastasis during the study period. The results revealed that PNI (HR 0.368, 95% CI 0.235-0.577; p < 0.001, Table 2), LMR (HR 0.383, 95% CI 0.223-0.657; p < 0.001, Table 2), and CALLY (HR 0.18, 95% CI 0.111-0.294; p < 0.001) were associated with progression free survival (PFS). Moreover, PNI (HR 0.252, 95% CI 0.137-0.461; p < 0.001, Table 3) and CALLY (HR 0.11, 95% CI 0.0.05-0.245; p < 0.001, Table 3) emerged as independent risk factors for postoperative lung metastasis. And PNI (p = 0.028, Table 5) is m...