Effects of sedatives on diaphragm activity monitored by ultrasound: a systematic review and meta-analysis

作者：Jiaren Luo, Luhao Wang, Bilin Wei, Zhikun Huang, Huifang Zheng, Bin Guo, Fei Pei, ZeNan Chang, Yang Liu, Xiangdong Guan, Xuyu Zhang, Zimeng Liu · 发表于：BMC Anesthesiology · 年份：2025 · DOI：10.1186/s12871-025-03187-8 · 被引用次数：2 · 研究领域：Ultrasound in Clinical Applications、Respiratory Support and Mechanisms、Thermal Regulation in Medicine

Current research lacks comprehensive evaluations on the inhibitory effects of sedatives on diaphragm activity under ultrasound monitoring. This meta-analysis aims to launch this problem by systematically analyzing the available evidence. The EMBASE, PubMed, and Web of Science databases were searched. Original studies that explored the effects of sedative agents on human diaphragm activity via ultrasound were eligible. The quality of the included studies was evaluated using the Revised Cochrane Risk-of-Bias tool for randomized trials (RoB 2) and the Newcastle–Ottawa Scale (NOS). The pooled assessment encompassed alterations in diaphragmatic motion (DM) and diaphragmatic thickening fraction (DTF). Mean difference (MD) with 95% confidence intervals (CI) were calculated. The trial sequential analysis (TSA) was performed to calculate the required information size (RIS). The strength of evidence was assessed using the Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) Pro Guideline Development Tool (GDT). Subgroup analysis and meta-regression was conducted to explore heterogeneity. Sensitivity analysis was used to evaluate the robustness for the meta-analysis results. Six randomized controlled trials and four prospective observational studies involving 727 patients were ultimately included. In the pooled analysis, DM and DTF were measured at three time points: during sedation (T1), upon awakening (T2), and at baseline (T0). Comparisons were conducted between ...