6-Deoxy-6-[18F]Fluoro-L-Ascorbic Acid PET/CT in the Detection of Lymph Node Metastases for Postoperative Differentiated Thyroid Cancer Patients

作者：Yali Long, Songhan Ge, Xiangdong Xu, Kunyuan Jiang, Yuying Zhang, Renbo Wu, Xiaoer Zhang, Jinyu Liang, Jianbo Liu, Qiao He, Weiming Lv, Xiangsong Zhang, Zhihao Zha · 发表于：Clinical Nuclear Medicine · 年份：2025 · DOI：10.1097/rlu.0000000000006026 · 被引用次数：2 · 研究领域：Thyroid Cancer Diagnosis and Treatment、Vitamin C and Antioxidants Research、Thyroid Disorders and Treatments

BACKGROUND: 6-Deoxy-6-[ 18 F]fluoro-L-ascorbic acid ([ 18 F]FAA) is a radioisotope-labeled analogue of ascorbic acid (AA), designed to investigate oxidative stress and AA accumulation in vivo by PET imaging. It has also been reported as a promising radiotracer for tumor detection, particularly in metastatic differentiated thyroid cancer (DTC). PURPOSE: This study aimed to evaluate the diagnostic potential of [ 18 F]FAA in detecting lymph node metastases in postoperative DTC patients. METHODS: Patients who have undergone thyroidectomy for DTC and are either preparing for 131 I therapy or undergoing follow-up examinations were prospectively enrolled and underwent [ 18 F]FAA PET/CT from September 2023 to November 2023. Histopathologic results served as gold standard for final diagnosis. RESULTS: A total of 70 patients [mean age, 40.5 y±12.0 (SD); 23 men] with pathologically confirmed DTC were enrolled. At patient-based analysis, [ 18 F]FAA PET/CT detected positive lymph nodes in all patients, with an accuracy of 92.9% (65/70). At lesion-based analysis of patients who underwent central and/or lateral cervical lymph node dissection, the accuracy of [ 18 F]FAA PET/CT were 94.3% (460/488). The SUVmax and TBR of lymph node metastases were significantly higher than normal lymph nodes (mean SUVmax, 8.3±4.6 vs. 2.0±1.5, P <0.0001; mean TBR, 3.6±2.2 vs. 0.9±0.7, P <0.0001). CONCLUSIONS: [ 18 F]FAA PET/CT can be used in the detection of postoperative cervical lymph node metastases in DTC....