Fluorescence indocyanine green (ICG) for sentinel-lymph-node mapping in colorectal cancer: a systematic review

作者：Alexis Litchinko, Jérémy Meyer, Léo H. Bühler, Frédéric Ris, Michel Adamina · 发表于：Langenbeck s Archives of Surgery · 年份：2025 · DOI：10.1007/s00423-025-03786-6 · 被引用次数：8 · 研究领域：Colorectal Cancer Surgical Treatments、Nanoplatforms for cancer theranostics、Pancreatic and Hepatic Oncology Research

OBJECTIVE: Modern surgical guidance in laparoscopic colon cancer procedures could be enhanced by visualizing lymphatic flow during surgery, already helping surgeons in determining the precise extent of digestive resection and could be useful in lymphadenectomy. Related to oncological procedure, lymphadenectomy is mandatory to assess the extension of the disease. To explore this approach, the objective of this review is to examine the use of indocyanine green fluorescence imaging for real-time in vivo identification of lymphatic flow and especially sentinel nodes in patients undergoing elective surgery for colorectal cancer. METHODS: A systematic review was conducted to identify relevant studies on sentinel node mapping using indocyanine green (ICG) in colorectal cancer surgery. A comprehensive search was performed in electronic databases including PubMed, Embase, and Cochrane Library from inception to December 2024. The search strategy incorporated relevant keywords and MeSH terms, combining variations of "colorectal neoplasms," "sentinel lymph node," "indocyanine green," and related terms. The search was limited to articles published in English language. RESULTS: A total of 405 studies were identified across all databases. After screening, 45 full-text articles were assessed for eligibility, and 12 studies were ultimately included in the systematic review. ICG-FI has not yet demonstrated superiority over the standard blue dye technique. Moreover, a notable heterogeneity exis...