Association of circadian syndrome with functional disability among middle-aged and older adults in China

作者：Yuhan Huang, Kaiyuan Wang, Yue He, Wenjing Wang, Chengxiang Hu, Kexin Jiang, Jiaqi Zhang, Yuchun Tao, Lina Jin · 发表于：The journal of nutrition health & aging · 年份：2025 · DOI：10.1016/j.jnha.2025.100621 · 被引用次数：8 · 研究领域：Circadian rhythm and melatonin、Climate Change and Health Impacts、Thermoregulation and physiological responses

BACKGROUND: Circadian syndrome (CircS) is a complex syndrome involving disorders of biological rhythms and multidimensional health risks. The objective of this research is to explore the association between CircS and functional disability. METHODS: This research utilized data from CHARLS, spanning the years 2011-2015. In the cross-sectional study, data from 12,758 Chinese adults aged 45 years and above in 2011 were used, and logistic regression models were employed to explore the association of CircS and its components with functional disability. A total of 8538 eligible subjects participated in the longitudinal study, and Cox regression models were used to analyze the longitudinal association and subgroup analysis. RESULTS: The cross-sectional analysis revealed positive associations of CircS with both ADL disability (OR = 1.68, 95% CI: 1.41, 2.00, p < 0.001) and IADL disability (OR = 1.74, 95% CI: 1.49, 2.04, p < 0.001). Longitudinal analysis also indicated that CircS was significantly associated with an elevated risk of developing both ADL disability (HR = 1.57, 95% CI: 1.33, 1.86, p < 0.001) and IADL disability (HR = 1.22, 95% CI: 1.05, 1.43, p = 0.012). Subgroup analysis found that the association between CircS and ADL disability had significant interactions with gender (p for interaction = 0.046) and smoking status (p for interaction < 0.001). CONCLUSION: Our findings find a positive association between CircS and functional disability, and the importance of gender and sm...