The predictive value of triglyceride glucose-body mass index for contrast-induced nephropathy in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention

作者：Litian Liu, Zheng Yuan, Xiaohui Ning, Jiaqi Wang, Yingxiao Li, Xuelian Song, Feifei Zhang · 发表于：Scientific Reports · 年份：2025 · DOI：10.1038/s41598-025-07212-1 · 被引用次数：1 · 研究领域：Acute Kidney Injury Research、Cardiac Imaging and Diagnostics、Acute Myocardial Infarction Research

Triglyceride glucose-body mass index (TyG-BMI) is an indicator of insulin resistance (IR) and is associated with an increased risk of adverse cardiovascular events. Insulin resistance (IR) is an important pathogenesis of diabetes mellitus, and also an important factor affecting the incidence and prognosis of cardiovascular diseases. However, the relationship between TyG-BMI and CIN in patients with STEMI has not been studied. STEMI patients who underwent percutaneous coronary intervention (PCI) between January 2017 and July 2020 were selected consecutively. The occurrence of contrast-induced nephropathy (CIN) is determined by the serum creatinine concentration. A total of 1041 patients (813; 78.1% male) with STEMI who underwent primary PCI were enrolled in this retrospective study. The registered cohort was divided into 2 groups according to whether the subjects developed CIN after surgery. CIN was defined as an increase in serum creatinine > 25% or 0.5 mg/dL from baseline in the first 48 to 72 h after PCI. A total of 201 cases (19.3%) of CIN were diagnosed. Compared with CIN (-) patients, CIN (+) patients had larger BMI, higher proportion of hypertension and hyperlipidemia, higher levels of fasting blood glucose, total cholesterol, triglyceride and uric acid, and higher levels of metabolic score for insulin resistance (METS-IR), triglyceride-glucose index (TyG) and TyG-BMI. Multivariate logistic regression analysis showed that TyG-BMI (OR = 1.029,95%CI 1.011-1.047, P = 0.002...