COVID-19 vaccine uptake in a retrospective population-based cohort of people living with and without HIV in Ontario, Canada

作者：Cassandra Freitas, Curtis Cooper, Abigail Kroch, Rahim Moineddin, Gordon Arbess, Anita C. Benoit, Sarah A. Buchan, Catharine Chambers, Muluba Habanyama, Claire Kendall, Jeffrey C. Kwong, Lawrence Mbuagbaw, John McCullagh, Nasheed Moqueet, Devan Nambiar, Sergio Rueda, Vanessa Tran, Sharon Walmsley, Ann N. Burchell · 发表于：Vaccine · 年份：2025 · DOI：10.1016/j.vaccine.2025.127422 · 被引用次数：3 · 研究领域：SARS-CoV-2 and COVID-19 Research、Vaccine Coverage and Hesitancy、Immune responses and vaccinations

INTRODUCTION: COVID-19 vaccination significantly reduces COVID-19-related hospitalization and mortality and is important for those who may be at increased risk of SARS-CoV-2 infection, including people living with HIV. Using a population-based approach, we examined COVID-19 vaccine uptake among people living with and without HIV in Ontario, Canada. METHODS: A retrospective population-based matched cohort study was conducted using provincial clinical and health administrative data from December 14, 2020 to August 31, 2022. Community-dwelling adults living with HIV aged ≥19 years were matched one-to-one with a person without a diagnosis of HIV based on age, sex, geography, and immigration status. To identify predictors of vaccine uptake, modified Poisson regression with robust standard errors accounting for geographical clustering was used. To estimate vaccine uptake comparing the HIV and non-HIV cohorts, conditional Poisson regression with robust error variance was used to estimate crude and adjusted risk ratios with 95 % confidence intervals (CI). RESULTS: Among 20,903 people living with HIV, most (85.4%) had received ≥2 COVID-19 vaccine doses, with 64.7% receiving a third dose and 24.3% receiving a fourth dose. Disparities in uptake of ≥3 doses by sex were observed (males vs females: 68.5% vs 50.9%). Predictors of receiving ≥3 doses among people living with HIV included older age, male sex, and receipt of a recent influenza vaccine. Men living with HIV were more likely to re...