Histopathological evaluation of the efficacy of carbon nanoparticle staining in detecting lymph node metastasis in colorectal cancer surgery

作者：Qingzhao Feng, Xin Zhang, Shuyang Yang, Yingqi Feng, Hong Chen, Jiafeng Wang, Zijian Li, Shuang Fu, Qi Sun, Min Feng · 发表于：Scientific Reports · 年份：2025 · DOI：10.1038/s41598-025-04621-0 · 被引用次数：3 · 研究领域：Colorectal Cancer Surgical Treatments、Pancreatic and Hepatic Oncology Research、Hepatocellular Carcinoma Treatment and Prognosis

The aim of this study is to conduct a retrospective analysis on the correlation between lymph node staining and lymph node metastasis following laparoscopic radical resection of colorectal cancer using a carbon nanoparticles tracer. Additionally, the study seeks to investigate the potential clinical implications of carbon nanoparticles (CNs) in the context of colorectal cancer surgery. Clinical data was collected from patients who underwent laparoscopic radical resection of colorectal cancer at a ward of the Department of General Surgery, Nanjing Drum Tower Hospital between January 2022 and December 2023. Patients were pathologically confirmed to have primary colorectal cancer with lymph node metastasis. The patients were divided into two groups based on whether they received carbon nanoparticle suspension injection under colonoscopy prior to the operation: the carbon nanoparticles group (CNs group, n = 80) and the control group (non-CNs group, n = 39). The histological sections of all lymph nodes were reviewed, assessing lymph node staining and tumor metastasis. There were no statistically significant differences in sex, age, body mass index, operation time, blood loss, tumor location, and postoperative pathological stage between the CNs group and the control group. However, the average number of lymph nodes differed significantly between the two groups (P = 0.001). A total of 1626 lymph nodes were obtained from the CNs group. Among these, 207 were identified as metastatic l...