Research Gaps, Challenges, and Opportunities in Automated Insulin Delivery Systems

作者：Peter G. Jacobs, Carol J. Levy, Sue A. Brown, Michael C. Riddell, Ali Çınar, Charlotte K. Boughton, Marc D. Breton, Eyal Dassau, Gregory P. Forlenza, Robert J. Henderson, Roman Hovorka, David M. Maahs, Medha Munshi, Helen R. Murphy, Sarit Polsky, Richard E. Pratley, Melissa S. Putman, Viral N. Shah, Leah M. Wilson, Howard Zisser, Laya Ekhlaspour · 发表于：Journal of Diabetes Science and Technology · 年份：2025 · DOI：10.1177/19322968251338754 · 被引用次数：8 · 研究领域：Diabetes Management and Research、Gestational Diabetes Research and Management、Pancreatic function and diabetes

BACKGROUND: Since the discovery of the life-saving hormone insulin in 1921 by Dr Frederick Banting in 1921, there have been many critical discoveries and technical breakthroughs that have enabled people living with type 1 diabetes (T1D) to live longer, healthier lives. The development of insulin pumps, continuous glucose monitoring (CGM) systems, and automated insulin delivery (AID) systems have enabled people living with T1D to safely manage their glucose, reduce their HbA1c, and improve their overall health and quality of life. Nevertheless, AID systems are not yet designed for all people with T1D, and they perform best during the overnight period when meals and exercise are not occurring. AID systems are not fully automated in that they require the person using the system to announce meals and exercise to the system to avoid dangerous hyper- or hypoglycemia, respectively. METHODS: In this review, which is one of a collection of manuscripts to commemorate the 75th anniversary of the National Institute for Diabetes and Digestive and Kidney Diseases, we celebrate the commercialization of the AID and discuss the major challenges and research gaps that remain to be solved to enable single- and multi-hormone AID systems to more fully support glucose management in people living with T1D. RESULTS: More research is required to design and evaluate more intelligent AID systems that do not require accurate carbohydrate estimations or announcements for meals and exercise. Current AID s...