Microbiota metabolites affect sleep as drivers of brain‑gut communication (Review)

作者：Ho Yu Cheng, Wanying Yang, Haijin Xu, Wenwen Zhu, Ailin Gong, Xuemei Yang, Sen Li, Houping Xu · 发表于：International Journal of Molecular Medicine · 年份：2025 · DOI：10.3892/ijmm.2025.5571 · 被引用次数：12 · 研究领域：Infant Health and Development、Pediatric health and respiratory diseases

Sleep plays a crucial role in maintaining and improving physical and mental health. However, the prevalence of sleep disorders is increasing in modern society. Recently, the gut‑brain axis has emerged as a prominent focus within the realm of sleep disorder research, with gut microbiota metabolites serving as essential factors in gut‑brain communication. The present study summarizes the emerging connections between gut microbiota metabolites and sleep, mainly focusing on those derived from tryptophan and dietary fiber metabolism. It discusses potential pathways and molecular processes by which sleep interacts with the gut microbiota metabolites, aiming to evaluate the feasibility of using gut microbiota interventions to treat sleep disorders.