Associations of healthy lifestyle and genetic susceptibility with risks of osteoarthritis: a prospective cohort study

作者：Shibo Chen, Yujie Zhang, Tianxiang Fan, Muhui Zeng, Qian Yang, Hao Yang, Xiaofeng Fang, Xingzhong Jin, Peihua Cao, Zhiqiang Wang, Yan Zhang, David J. Hunter, Yuan Zhou, Changhai Ding, Zhaohua Zhu, Cindy G. Boer, Konstantinos Hatzikotoulas, Lorraine Southam, Lilja Stefánsdóttir, Yanfei Zhang, Rodrigo Coutinho de Almeida, Tian T Wu6, Jie Zheng, April Hartley, Maris Teder‐Laving, Anne Heidi Skogholt, Chikashi Terao, Eleni Zengini, George Alexiadis, Andrei Barysenka, Gyða Björnsdóttir, Maiken E. Gabrielsen, Arthur Gilly, Þorvaldur Ingvarsson, Marianne Bakke Johnsen, Helgi Jónsson, M. Kloppenburg, Almut Luetge, Sigrún H. Lund, Reedik Mägi, Massimo Mangino, Rob G. H. H. Nelissen, Manu Shivakumar, Julia Steinberg, Hiroshi Takuwa, Laurent F. Thomas, Margo Tuerlings, George C. Babis, Jason Pui Yin Cheung, Jae Hee Kang, Peter Kraft, Steven A. Lietman, Dino Samartzis, P. Eline Slagboom, Kāri Stefánsson, Unnur Thorsteinsdottir, Jonathan H. Tobias, André G. Uitterlinden, Bendik S Winsvold, John‐Anker Zwart, George Davey Smith, Pak C. Sham, Guðmar Þorleifsson, Tom R. Gaunt, Andrew P. Morris, Ana M. Valdes, Aspasia Tsezou, Kathryn S.E. Cheah, Shiro Ikegawa, Kristian Hveem, Tõnu Esko, J. Mark Wilkinson, Ingrid Meulenbelt, Ming Ta Michael Lee, Joyce B. J. van Meurs, Unnur Styrkársdóttir, Eleftheria Zeggini · 发表于：Lara D. Veeken · 年份：2025 · DOI：10.1093/rheumatology/keaf327 · 被引用次数：4 · 研究领域：Osteoarthritis Treatment and Mechanisms、Fibromyalgia and Chronic Fatigue Syndrome Research、Genetic Associations and Epidemiology

OBJECTIVES: To detect the associations of a healthy lifestyle and genetic susceptibility with incident OA in the UK Biobank study. METHODS: We included 314 729 participants from UK Biobank. Five modifiable lifestyle factors including weight management, diet, physical activity, sleep behaviour and sedentary behaviour were included to generate an overall lifestyle score. Genetic susceptibility was calculated by using polygenic risk score (PRS) of OA. Participants diagnosed with OA were identified by using the International Classification of Diseases (ICD)-9 and ICD-10. Covariates included age, sex, education, Townsend deprivation index, glucosamine use, analgesics use and comorbidities. Cox regression analyses were performed to examine the associations of genetic susceptibility and healthy lifestyle with incident OA. RESULTS: Adopting a more favourable lifestyle can be beneficial in significantly reducing the risk of incident total, knee and hip OA (all P < 0.01). PRS was significantly associated with greater risks of total, knee and hip OA. Compared with unfavourable lifestyle, favourable lifestyle was significantly associated with a lower risk of total OA across low [hazard ratio (HR) 0.64; 95% CI 0.58-0.70], intermediate (HR 0.59; 95% CI 0.56-0.63) and high (HR 0.58; 95% CI 0.53-0.64) genetic risk groups. Similar results were observed on knee OA and hip OA. No significant interactions were detected between lifestyle and PRS for total, knee or hip OA. CONCLUSION: These data s...