Amomaxyz A and B, Sesquiterpene-Indole Alkaloids from Fruits of Amomum maximum Roxb

作者：Shufei Yu, Jin‐Na Zhao, Bo Li, Yanjun Ding, M. He, Zhihang Wu, Lu Chen, Ze Li, Y. D. Qu, Jian Huang, Xianmei Piao, Jinhui Wang, Li-Bo Wang · 发表于：Journal of Natural Products · 年份：2025 · DOI：10.1021/acs.jnatprod.5c00539 · 被引用次数：6 · 研究领域：Ginger and Zingiberaceae research、Piperaceae Chemical and Biological Studies、Medicinal Plants and Neuroprotection

Two unprecedented 4/9/5-membered ring sesquiterpene-indole alkaloids, amomaxyz A ( 1 ) and B ( 2 ), along with one known compound caryolane-1,9β-diol ( 3 ), were isolated from the fruit of Amomum maximum Roxb. Their structures and absolute configurations were elucidated through comprehensive spectroscopic analyses, including NMR, electronic circular dichroism (ECD), X-ray single-crystal diffraction, and DP4 probability analysis of calculated NMR data. Biological evaluation revealed distinct anti-inflammatory and anticancer activities. 1 demonstrated dose-dependent anti-inflammatory activity by suppressing NO release in LPS/IFN-γ-activated RAW264.7 macrophages (25.9% at 10 μM, 29.9% at 20 μM; P < 0.01), while 2 and 3 exhibited weaker effects. Moreover, 1 (IC 50 = 30.62 μM) and 2 (IC 50 = 23.43 μM) showed moderate inhibitory effects against HepG2 cells, which reveals the potential of their biological activity.