Insights from fifteen years of real-world development, testing and implementation of youth digital mental health interventions

作者：Shane Cross, Shaminka N. Mangelsdorf, Lee Valentine, Shaunagh O’Sullivan, Carla McEnery, Isabelle Scott, Tamsyn Gilbertson, Shona Louis, Jon H. Myer, Ping Liu, Niel Mac Dhonnagáin, Tom Wren, Eleanor Carey, Daniela Cagliarini, Ross Jacobs, Roos Pot-Kolder, Imogen Bell, Jennifer Nicholas, Lucia Valmaggia, John Gleeson, Mario Álvarez‐Jiménez · 发表于：Internet Interventions · 年份：2025 · DOI：10.1016/j.invent.2025.100849 · 被引用次数：8 · 研究领域：Digital Mental Health Interventions、Impact of Technology on Adolescents、Mental Health Research Topics

This paper reviews the current evidence and synthesizes fifteen years of real-world development, testing, and implementation of digital mental health interventions (DMHIs) for young people. Drawing on the work of Orygen Digital, we outline the evolution of interventions including the Moderated Online Social Therapy (MOST) platform, the Mello app, and a suite of virtual reality-based therapies; all developed to meet the complex clinical, developmental, and service needs of youth aged 12 to 25. We identify ten key challenges and opportunities encountered in designing, developing and implementing these DMHIs: (1) meaningful co-design; (2) sustained user engagement; (3) personalization and transdiagnostic targeting; (4) optimizing intensities of human support; (5) leveraging peer support and social networking; (6) embedding DMHIs in clinical services; (7) blending digital and face-to-face care; (8) building data infrastructure and learning health systems; (9) developing sustainable and scalable business models; and (10) preparing DMHIs for large language models. Each theme reflects both achievements and persistent challenges, and is illustrated through a synthesis of the current evidence and real-world insights from our clinical trials and national-scale service implementations. Our approach is grounded in various frameworks including clinical staging, self-determination theory, supportive accountability, and minimally disruptive medicine. Emerging innovations such as just-in-tim...