Predictive model for CRT risk in cancer patients with central venous access devices: a systematic review and meta-analysis

作者：Wenjuan Yang, Meng Fang, Kangqin Cai, Qin Pan, Cheng Zhang, Jiquan Zhang · 发表于：Frontiers in Medicine · 年份：2025 · DOI：10.3389/fmed.2025.1580920 · 被引用次数：1 · 研究领域：Central Venous Catheters and Hemodialysis、Venous Thromboembolism Diagnosis and Management、Vascular Procedures and Complications

Introduction: With the high incidence of central venous access device catheter-related thrombosis (CRT) in patients with cancer, its early onset, and the characteristics of clinically insignificant symptoms, risk assessment is essential for the targeted application of thromboprophylaxis. The aim of this paper was to review the risk prediction models developed for central venous access device CRT in patients with cancer and to evaluate their performance. Methods: PubMed, Embase, Web of Science, Cochrane Library, CNKI, SinoMed, Wanfang Data, and VIP databases were searched, and the search timeframes ranged from the establishment of the database to May 22, 2024. Two researchers independently performed literature screenings, data extractions, and quality assessments. The risk of bias and applicability of the included studies were assessed using the Predictive Model Risk of Bias Assessment Tool. A meta-analysis of the areas under the curve (AUC) values for model validation was performed using Stata 17.0 software. Results: Nineteen papers with 29 predictive models were included in this systematic review, reporting AUC values of 0.470-1.000. The incidence of central venous access device CRT in cancer patients ranges from 2.02 to 39.4%. The most commonly used predictors are D-dimer levels, BMI, and diabetes. All studies were judged to have a high risk of bias, mainly due to poor reporting of the areas analyzed. The combined AUC value of the six validated models was 0.81 (95% confiden...