Chronic hepatitis B virus persistence: Mechanisms, consequences and implications for achieving cure

作者：Christopher Georgi, Simmone D’souza, Carla Osiowy, Carla S. Coffin, Curtis Cooper · 发表于：Annals of Hepatology · 年份：2025 · DOI：10.1016/j.aohep.2025.101938 · 被引用次数：12 · 研究领域：Hepatitis B Virus Studies、Hepatitis C virus research、Liver Disease Diagnosis and Treatment

HBV persists within the hepatocyte due to the presence of intranuclear covalently closed circular DNA (cccDNA) and double-stranded linear DNA (dslDNA) integration. These bodies pose formidable challenges for achieving HBV functional and sterilizing cure. In this virology-focused review we provide an overview of HBV persistence with consideration of the negative implications for chronic infection. We also discuss advancements in HBV therapies that aim to disrupt these targets.