Interventions for adolescent depression comorbid with non-suicidal self-injury: a scoping review

作者：Shihan Fang, Fazhan Chen, Jing Bian, Lei Zhang, Yanbo Wang · 发表于：Frontiers in Psychiatry · 年份：2025 · DOI：10.3389/fpsyt.2025.1601073 · 被引用次数：6 · 研究领域：Suicide and Self-Harm Studies、Digital Mental Health Interventions、Personality Disorders and Psychopathology

Background: Adolescent depression and non-suicidal self-injury (NSSI) represent significant global public health challenges, with high comorbidity rates and multidimensional adverse outcomes. Despite growing evidence on interventions, a comprehensive synthesis of strategies targeting this co-occurrence remains limited. Aim: This scoping review systematically maps evidence-based interventions for adolescents with comorbid depression and NSSI, focusing on efficacy, mechanisms, and implementation challenges. Methods: Following Arksey and O'Malley's framework and PRISMA-ScR guidelines, a systematic search of English and Chinese databases (2000-2025) identified 18 studies (13 randomized controlled trials [RCTs], 3 quasi-experimental studies, and 2 other study designs). Data were extracted and synthesized to characterize intervention types, outcomes, and contextual factors. Results: Psychotherapies, particularly dialectical behavior therapy for Adolescents (DBT-A), demonstrated robust efficacy, reducing NSSI frequency by 50% and relapse rates through enhanced emotion regulation. Family-system approaches (e.g., Satir therapy) improved family cohesion and reduced comorbid behaviors. Pharmacological agents (e.g., Selective Serotonin Reuptake Inhibitors) showed synergistic effects when combined with psychotherapy, while neuromodulation (e.g., Repetitive Transcranial Magnetic Stimulation) normalized neuroinflammatory markers. Innovations like narrative therapy facilitated identity recon...