Liver-targeted degradation of BRD4 reverses hepatic fibrosis and enhances metabolism in murine models

作者：Shengjie Yuan, Ayesha Nisar, Chuanjie Chen, Xin Dong, Yongzhang Pan, Meiting Zi, Qiong Wang, Sawar Khan, Yaxun Guo, Xuan Zhang, Yonghan He · 发表于：Theranostics · 年份：2025 · DOI：10.7150/thno.113852 · 被引用次数：15 · 研究领域：Protein Degradation and Inhibitors、Peptidase Inhibition and Analysis、Chromatin Remodeling and Cancer

These results highlight the therapeutic potential of LIVTAC XZ1606 in reversing liver fibrosis and steatosis through targeted BRD4 degradation, offering a novel and selective approach for chronic liver disease treatment.