Neutrophil extracellular traps aggravate neuronal apoptosis and neuroinflammation via neddylation after traumatic brain injury

作者：Xianghua Zhang, Jianye Xu, Yonggang Fan, Guihong Shi, Bo Chen, Anni Wang, Yanlin Zhu, Lei Li, Haoran Jia, Dilmurat Gheyret, Jinchao Wang, Yiyao Cao, Shenghui Li, Xin Chen, Jianning Zhang, Shu Zhang · 发表于：Theranostics · 年份：2025 · DOI：10.7150/thno.111512 · 被引用次数：25 · 研究领域：Neutrophil, Myeloperoxidase and Oxidative Mechanisms、Traumatic Brain Injury and Neurovascular Disturbances、Neurological Disorders and Treatments

Our study revealed that NETs trigger neuronal death and neuroinflammation via neddylation. We propose that inhibiting neddylation could offer therapeutic benefits in TBI.