Animal models of critical care illnesses: current reality, future directions

作者：John F. Fraser, Shigeaki Inoue, Yongming Yao, Marcin F. Osuchowski · 发表于：Intensive Care Medicine Experimental · 年份：2025 · DOI：10.1186/s40635-025-00776-2 · 被引用次数：3 · 研究领域：Anesthesia and Neurotoxicity Research、Respiratory Support and Mechanisms、Thermal Regulation in Medicine

Critical care medicine addresses multiple life-threatening conditions including sepsis, polytrauma, shock and acute respiratory distress syndrome (ARDS) as well as recent global threats like COVID-19.Advancing clinical improvements for patients suffering from these illnesses is contingent upon understanding of their complex pathophysiology, developing precise/rapid diagnostic tools and effective therapies.Animal models have long served as a cornerstone of this endeavor offering invaluable discoveries including first test of closed-chest cardiac massage technique in 1959 (developed in dogs) and first use of anti-SARS-CoV-2 vaccine in 2020 (tested in rodents and non-human primates).