Global burden of vision impairment due to age-related macular degeneration, 1990–2021, with forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2021

作者：Yi Deun Jeong, Seoyoung Park, Min Seo Kim, Sung Hwi Hong, Hasan Aalruz, Yohannes Abate, Rouzbeh Abbasgholizadeh, Samar Abd ElHafeez, Auwal Abdullahi, Richard Gyan Aboagye, Lucas Guimarães Abreu, Ahmed Abu‐Zaid, Isaac Yeboah Addo, Habeeb Omoponle Adewuyi, Saira Afzal, Williams Agyemang‐Duah, Aqeel Ahmad, Danish Ahmad, Sajjad Ahmad, Ali Ahmadi, Hooman Ahmadzadeh, Ali Ahmed, Ayman Ahmed, Haroon Ahmed, Syed Anees Ahmed, Amjad S Al Mosa, Rasmieh Al‐Amer, Mohammed ALBashtawy, Ahmad Samir Alfaar, Abdelazeem M. Algammal, Fadwa Alhalaiqa, Abid Ali, Syed Shujait Ali, Waad Ali, Ahmad Alrawashdeh, Awais Altaf, Vera Lúcia Alves Carneiro, Yaser Mohammed Al‐Worafi, Hany Aly, Sofia Androudi, Boluwatife Stephen Anuoluwa, Saeid Anvari, Anayochukwu Edward Anyasodor, Jalal Arabloo, Mosab Arafat, Aleksandr Y. Aravkin, Demelash Areda, Anton A Artamonov, Akram M. Asbeutah, Seyyed Shamsadin Athari, Maha Atout, Alok Atreya, Lemessa Assefa A Ayana, Shahkaar Aziz, Ahmed Y. Azzam, Saeed Bahramian, Ruhai Bai, Atif Amin Baig, Soham Bandyopadhyay, Zarrin Basharat, Mohammad‐Mahdi Bastan, Maryam Bemanalizadeh, Akshaya Srikanth Bhagavathula, Nikha Bhardwaj, Pankaj Bhardwaj, Sonu Bhaskar, Ajay Nagesh Bhat, Jasvinder Singh Bhatti, Fassikaw Kebede Bizuneh, Paul Svitil Briant, Gabrielle B. Britton, Yasser Bustanji, Zahid A Butt, Florentino Luciano Caetano dos Santos, Mehtap Çakmak Barsbay, Fan Cao, Vijay Kumar Chattu, Anis Ahmad Chaudhary, Patrick R Ching, Hitesh Chopra, Sonali G Choudhari, Dinh‐Toi Chu, João Coelho, Natália Martins, Omid Dadras, Xiaochen Dai, Emanuele D’Amico, Samuel Demissie Darcho, Ana Maria Dascălu, Nihar Ranjan Dash, Mohsen Dashti, Άννα Δαστιρίδου, Nikolaos Dervenis, Aragaw Tesfaw Desale, Vinoth Gnana Chellaiyan Devanbu, Amol S. Dhane, Daniel Díaz, Michael J. Diaz, Thanh Chi, Ojas Prakashbhai Doshi, Ashel Chelsea Dsouza, Hisham Atan Edinur, Ferry Efendi, Michael Ekholuenetale, Rabie Adel El Arab, Ibrahim Farahat El Bayoumy, Muhammed Elhadi, Chadi Eltaha, Mohammad Hassan Emamian, Adeniyi Francis Fagbamigbe, Ayesha Fahim, Hossein Farrokhpour, Ali Fatehizadeh, Timur Fazylov, Alireza Feizkhah, Ginenus Fekadu, Nuno Ferreira, Florian Fischer, Ida Fitriana, Ali Forouhari, Matteo Foschi, João M. Furtado, Blima Fux, G Sridevi, Muktar A Gadanya, Abhay Gaidhane, Aravind P. Gandhi, Balasankar Ganesan, Ravindra Kumar Garg, Rupesh K. Gautam, Miglas Welay Gebregergis, Mesfin Gebrehiwot, Delaram J. Ghadimi, Sadegh Ghafarian, Mahaveer Golechha, Pouya Goleij, Ayman Grada, Shi‐Yang Guan, Snigdha Gulati, Sapna Gupta, Veer Bala Gupta, Vivek Gupta, Roberth Steven Gutiérrez-Murillo, Awoke Derbie Habteyohannes, Arvin Haj-Mirzaian, Sobia Ahsan Halim, Ahmed I Hasaballah, Md. Kamrul Hasan, Hamidreza Hasani, Jiawei He, Golnaz Heidari, Mojtaba Heydari, Nguyen Quoc Hoan, Ramesh Holla, Mehdi Hosseinzadeh, Chengxi Hu, Junjie Huang, Salman Hussain, Segun Emmanuel Ibitoye, Nayu Ikeda, Irena Ilić, Milena Ilić, Mustapha Immurana, Arit Inok, Lalu Muhammad Irham, Md. Rabiul Islam, Sheikh Mohammed Shariful Islam, Chidozie Declan Iwu, Louis Jacob, Ammar Abdulrahman Jairoun, Mihajlo Jakovljević, Talha Jawaid, Shubha Jayaram, Zixiang Ji, Jost B. Jonas, Nitin Joseph, Charity Ehimwenma Joshua, Vidya Kadashetti, Ankita Kankaria, Kehinde Kazeem Kanmodi, Neeti Kapoor, Ibraheem M. Karaye, Soujanya Kaup, Gbenga A Kayode, Yousef Khader, Himanshu Khajuria, Ajmal Khan, Atulya Aman Khosla, Yun Jin Kim, Adnan Kısa, KM Shivakumar, Kewal Krishan, Mohammed Kuddus, Mukhtar Kulimbet, Nithin Kumar, Satyajit Kundu, Chandrakant Lahariya, Dharmesh Kumar Lal, Iván Landires, Van Charles Lansingh, Ariane Laplante-Lévesque, Caterina Ledda, Munjae Lee, Seung Won Lee, Wei‐Chen Lee, Stephen S Lim, Xuefeng Liu, José Francisco López‐Gil, Zheng Feei, Kashish Malhotra, Vahid Mansouri, Roy Rillera Marzo, Alireza Mashaghi, Yasith Mathangasinghe, Andrea Maugeri, Asim Mehmood, Tesfahun Mekene Meto, Hadush Negash Meles, Endalkachew Belayneh Melese, Tomislav Mestrovic, Sachith Mettananda, Irmina Maria Michałek, Andreea Mirică, Abdalla Z. Mohamed, Nouh Saad Mohamed, Abdollah Mohammadian-Hafshejani, Ali H. Mokdad, Fateme Montazeri, Maryam Moradi, Rohith Motappa, Sumaira Mubarik, Kavita Munjal, Yanjinlkham Munkhsaikhan, Amin Nabavi, Ganesh R. Naik, Vinay Nangia, Shumaila Nargus, Zuhair S. Natto, Muhammad Naveed, Biswa Prakash Nayak, Athare Nazri-Panjaki, Văn Thành Nguyễn, Robina Khan Niazi, Syed Toukir Ahmed Noor, Mamoona Noreen, Fred Nugen, Bogdan Oancea, Osamudiamen Cyril Obasuyi, Andrew T Olagunju, Sok King Ong, Michał Ordak, Verner N. Orish, Mayowa Owolabi, Jagadish Rao Padubidri, Georgios D. Panos, Leonidas D Panos, Shahina Pardhan, Romil R Parikh, Sungchul Park, Tae Hwan Park, Maja Pasovic, Roberto Passera, Jay Patel, Shrikant Pawar, Prince Peprah, Arokiasamy Perianayagam, Mohsen Pourazizi, Jalandhar Pradhan, Jagadeesh Puvvula, Nameer Hashim Qasim, Venkatraman Radhakrishnan, Pankaja Raghav, Fakher Rahim, Vafa Rahimi‐Movaghar, Mohammad Hifz Ur Rahman, Mosiur Rahman, Muhammad Aziz Rahman, Shayan Rahmani, Mohammad Rahmanian, Pushp Lata Rajpoot, Sowmya J Rao, Mohammad‐Mahdi Rashidi, Salman Rawaf, Elrashdy M. Redwan, Mohsen Rezaeian, Sara Riaz, Moustaq Karim Khan Rony, Himanshu Sekhar Rout, Priyanka Roy, Aly M A Saad, Zahra Saadatian, Cameron Sabet, Basema Ahmad Saddik, Umar Saeed, Sare Safi, Sher Zaman Safi, Fatemeh Saheb Sharif‐Askari, Narjes Saheb Sharif‐Askari, Amirhossein Sahebkar, Pragyan Monalisa Sahoo, S. Mohammad Sajadi, Mohamed A. Saleh, Yoseph Leonardo Samodra, Abdallah M Samy, T. Sarkar, Brijesh Sathian, Maheswar Satpathy, Jennifer Saulam, Monika Sawhney, Ganesh Kumar Saya, Siddharthan Selvaraj, Yashendra Sethi, Allen Seylani, Jaffer Shah, Amira Shaheen, Samiah Shahid, Moyad Shahwan, Masood Ali Shaikh, Muhammad Aaqib Shamim, Javad Sharifi‐Rad, Anupam Kumar Sharma, Vishal Sharma, Maryam Shayan, Mahabalesh Shetty, Pavanchand H Shetty, Premalatha K Shetty, Mika Shigematsu, Aminu Shittu, Negussie Boti Sidamo, Emmanuel Edwar Siddig, Mithun Sikdar, Jasvinder A. Singh, Paramdeep Singh, Puneetpal Singh, Surjit Singh, Raúl A. R. C. Sousa, Chandrashekhar T Sreeramareddy, Chandan Kumar Swain, Łukasz Szarpak, Seyyed Mohammad Tabatabaei, Ker‐Kan Tan, Hugh R. Taylor, Mohamad‐Hani Temsah, Ramna Thakur, Jansje Henny Vera Ticoalu, Krishna Kant Tiwari, Marcos Roberto Tovani‐Palone, Ngoc Ha Tran, Thang Huu Tran, Munkhtuya Tumurkhuu, Saeed Ullah, Muhammad Umair, Sanaz Vahdati, Shaopan Wang, Muhammad Waqas, Nuwan Darshana Wickramasinghe, Kazumasa Yamagishi, Amir Yarahmadi, Pengpeng Ye, Arzu Yiğit, Yazachew Engida Yismaw, Naohiro Yonemoto, Aurora Zanghì, Mohammed G M Zeariya, Zhi-Jiang Zhang, Claire Chenwen Zhong, Abzal Zhumagaliuly, Makan Ziafati, Magdalena Zielińska, Sa’ed H. Zyoud, Jae Il Shin, Dong Keon Yon · 发表于：The Lancet Global Health · 年份：2025 · DOI：10.1016/s2214-109x(25)00143-3 · 被引用次数：59 · 研究领域：Ophthalmology and Visual Impairment Studies、Retinal Diseases and Treatments、Retinopathy of Prematurity Studies

BACKGROUND: Age-related macular degeneration (AMD) is a growing public health concern worldwide, as one of the leading causes of vision impairment. We aimed to estimate global, national, and region-specific prevalence and disability-adjusted life-years (DALYs) along with tobacco as a modifiable risk factor to aid public policy addressing AMD. METHODS: Data on AMD were extracted from the Global Burden of Disease, Injuries, and Risk Factor Study 2021 database in 204 countries and territories, 1990-2021. Vision impairment was defined and categorised by severity as follows: moderate to severe vision loss (visual acuity from <6/18 to 3/60) and blindness (visual acuity <3/60 or a visual field <10 degrees around central fixation). The burden of vision impairment attributable to AMD was subsequently estimated. These estimates were further stratified by geographical region, age, year, sex, Healthcare Access and Quality (HAQ) Index, and Socio-demographic Index (SDI) levels. Additionally, the effect of tobacco use, a modifiable risk factor, on the burden of AMD was analysed, and projections of AMD burden were estimated through to 2050. These projections also included scenario modelling to assess the potential effects of tobacco elimination. FINDINGS: Globally, the number of individuals with vision impairment due to AMD more than doubled, rising from 3·64 million (95% uncertainty inverval [UI] 3·04-4·35) in 1990 to 8·06 million (6·71-9·82) in 2021. Similarly, DALYs increased by 91% over ...