Metal–Organic Framework-Based Self-Powered Chemodynamic Therapy Nanosystem: CaO 2 @PCN-222(Fe) and Its Mixed Matrix Membranes for Promoting Infected Wound Healing

作者：Han-Xiao Feng, Xiaodong Su, Dahai Hu, Yi-Fei Hui, Hongxin Su, Jilin Jiang, Ruyi Ji, Shulin Li, Zu‐Jin Lin, Faqiang Tang · 发表于：Inorganic Chemistry · 年份：2025 · DOI：10.1021/acs.inorgchem.5c02508 · 被引用次数：8 · 研究领域：Nanoplatforms for cancer theranostics、Advanced Nanomaterials in Catalysis、Graphene and Nanomaterials Applications

Bacterial infections pose an increasing threat to human health. Chemodynamic therapy (CDT), which utilizes nanozymes to catalyze H 2 O 2 into highly toxic hydroxyl radicals (·OH), offers a promising disinfection strategy because of its high efficacy, broad-spectrum antibacterial activity, and low risk of inducing drug resistance. Herein, we developed a self-powered CDT nanocomposite, CaO 2 @PCN-222(Fe), via a facile one-pot synthesis for wound disinfection. In infected wounds, the CaO 2 component of the composite gradually hydrolyzes to H 2 O 2, while the PCN-222(Fe) component acts as peroxidase mimics to efficiently catalyze the generated H 2 O 2 into ·OH, thus achieving self-powered CDT. In vitro assays confirmed that the minimum bactericidal concentration of the composite against Staphylococcus aureus is as low as 31.25 μg mL –1 . Furthermore, in vivo assays demonstrated that the composite could effectively accelerate infected wound healing. To broaden application scenarios, the composite was further integrated into poly(vinylidene fluoride) (PVDF) to form CaO 2 @PCN-222(Fe)@PVDF mixed matrix membranes (MMMs), which inherit the self-powered CDT capability, exhibiting high antimicrobial activity and promoting infected wound healing. Notably, no significant toxicity was observed for CaO 2 @PCN-222(Fe) and its MMMs. This work presents an efficient self-powered CDT modality, combining the advantages of CaO 2 and peroxidase mimics for treating bacterial infections and promoting...