Alopecia Secondary to Hyaluronic Acid Injection: A Case Report and Literature Review

作者：Lingling Jia, Jiachao Xiong, Changjiang Zhao, Hua Jiang, Yufei Li · 发表于：Clinical Cosmetic and Investigational Dermatology · 年份：2025 · DOI：10.2147/ccid.s524217 · 被引用次数：4 · 研究领域：Facial Rejuvenation and Surgery Techniques、Hair Growth and Disorders、Dermatologic Treatments and Research

Background: Hyaluronic acid injections, commonly used for anti-aging purposes, carry potential risks, including transient or permanent alopecia, a complication not yet fully characterized. This adverse effect can result from various mechanisms, such as pressure, ischemia, inflammation, and necrosis. Objective: This study aimed to present a case report of a patient treated with Concentrated Growth Factor combined with microneedling and minoxidil for alopecia following hyaluronic acid injection in the left temporal scalp and to systematically review literature from January 2000 to December 2024 on alopecia secondary to hyaluronic acid injections. Methods: A 23-year-old woman developed a 5×6.5 cm alopecic patch on the left temporal scalp just four days after receiving 5 mL of Restylane hyaluronic acid filler in the frontal area. Despite initial treatment with 1500 units of hyaluronidase, alopecia progressed. A multimodal therapy was then initiated, including Concentrated Growth Factor injections, microneedling, and topical 5% minoxidil, delivered over three sessions at 1-2-week intervals. A systematic literature search (PubMed/Web of Science/Embase, 2000-2024) identified 13 relevant articles reporting on 19 cases of hyaluronic acid-induced alopecia for analysis. Results: In the case report, the patient experienced full hair regrowth after treatment with Concentrated Growth Factor, microneedling, and minoxidil. Additionally, thirteen full-text articles involving 19 patients with ...