Resveratrol: Harnessing Nature's Potential for Chronic Pain Relief

作者：Hong Wu, Jiayi Wu, Shao‐Jie Gao, Lin Liu, Xinyi Dai, Wenlu Song, Long-Qing Zhang, Dai-Qiang Liu, Yingxin Tang, Ya‐Qun Zhou, Wei Mei · 发表于：Aging and Disease · 年份：2025 · DOI：10.14336/ad.2025.0530 · 被引用次数：4 · 研究领域：Sirtuins and Resveratrol in Medicine、Pain Mechanisms and Treatments、Adipose Tissue and Metabolism

Resveratrol, a natural polyphenol with anti-inflammatory, antioxidant, and neuroprotective properties, shows great potential in managing chronic pain. This review explores its analgesic mechanisms, including the inhibition of neuroinflammation, enhancement of antioxidant activity, induction of autophagy, reduction of endoplasmic reticulum stress, modulation of the serotonin system, restoration of gut microbiota homeostasis, regulation of the neuroendocrine system, and promotion of mitochondrial biogenesis. While its analgesic potential is considerable, future research should prioritize enhancing its bioavailability, investigating drug interactions, and confirming long-term safety to develop more effective therapies for chronic pain.