Long-term outcomes of single-incision laparoscopic surgery for colorectal cancer, a single-center, open-label, randomized controlled trial

作者：Zijia Song, Yiqing Shi, Xianze Chen, Yimei Jiang, You Li, Changgang Wang, Jun Li, Yaqi Zhang, Haiyan Huang, K. Liu, Ren Zhao · 发表于：International Journal of Surgery · 年份：2025 · DOI：10.1097/js9.0000000000002788 · 被引用次数：5 · 研究领域：Minimally Invasive Surgical Techniques、Colorectal Cancer Surgical Treatments、Surgical Simulation and Training

BACKGROUND: The efficacy of single-incision laparoscopic surgery (SILS) for colorectal cancer remains controversial due to uncertainties regarding long-term outcomes. This study aimed to compare the 5-year outcomes of SILS and conventional laparoscopic surgery (CLS) for colorectal cancer in a randomized clinical trial. METHODS: This trial was a single-center, open-label, non-inferiority, randomized clinical trial conducted at our hospital. Patients aged 18-85 years who were diagnosed with or suspected of having colorectal cancer (staged cT1-4aN0-2M0) were enrolled. Neither the patients nor investigators were blinded to treatment allocation. The final follow-up date was on August 1, 2024. Participants were randomly assigned to either the SILS or CLS group in a 1:1 ratio using the random number table method. Both groups underwent surgery following the same oncological principles, including complete mesocolic excision for colon cancer and total mesorectal excision for rectal cancer with D3 lymph node dissection. The primary outcome was the early morbidity rate, which was reported previously. Here, we primarily report the long-term outcomes analyzed in the modified intention-to-treat (mITT) population, including 5-year disease-free survival (DFS), overall survival (OS), incisional hernia incidence, and recurrence patterns. RESULTS: A total of 200 patients were enrolled between June 28, 2017 and June 29, 2019. Of these, 193 (110 men [57.0%]; median (interquartile range [IQR]) age,...