Visible Light‐Driven Deracemization of Cyclic Sulfonamides by Quinuclidine and Chiral Arylthiol Catalysis

作者：Lei Dai, Chaoren Shen, Jing Wang, Yanzhong Li, Kaiwu Dong · 发表于：Angewandte Chemie International Edition · 年份：2025 · DOI：10.1002/anie.202505719 · 被引用次数：12 · 研究领域：Sulfur-Based Synthesis Techniques、Radical Photochemical Reactions、Catalytic C–H Functionalization Methods

-symmetric arylthiol was developed for the deracemization of various cyclic sulfonamides. This protocol exhibited high yields, good to excellent enantioselectivity, and broad substrate scope. The resulting products can be readily transformed into diverse diarylmethylamines, presenting a viable alternative to metal-catalyzed asymmetric methods. The reaction pathway involving a relay of non-enantioselective hydrogen-atom abstraction (HAA) and enantioselective hydrogen-atom delivery (HAD).