Optical Biosensors Utilizing Polymer-Based Athermal Integrated Photonic Devices

作者：Hongqiang Li, Fanglin Xie, Xiaolin Li, Ming Han, Yueting Yang, Junqu Zhang, Lizhen Zhang, Yingjie Wang, Lu Cao, Enbang Li · 发表于：ACS Sensors · 年份：2025 · DOI：10.1021/acssensors.5c01046 · 被引用次数：1 · 研究领域：Photonic and Optical Devices、Analytical Chemistry and Sensors、Advanced Fiber Optic Sensors

In applications subject to temperature variations, developing temperature-insensitive photonic waveguide devices is crucial for ensuring the stability of wavelength-filtering devices. Here, we develop a polymer-based athermal photonic chip for optical biosensing. We adopt polydimethylsiloxane and poly(methyl methacrylate) as the waveguide materials and NOA61 as the substrate and propose an athermal optical demodulator photonic chip for physiological measurement on the basis of mutual compensation of the thermal optical effect and thermal expansion effect. The waveguide Bragg grating photonic sensor for measuring blood glucose and pressure has good temperature stability, and its temperature sensitivity can be reduced to -13.81-13.4 pm/°C. In the temperature range of 20-50 °C, the sensitivity of blood glucose measurement is 208.4 pm/(mg/mL), and the accuracy of blood glucose concentration measurement is 92.766% for 0-1.5 mg/mL; the sensitivity of the pressure measurement is 610 pm/kPa, and a pressure demodulation of 0-12 kPa can be achieved. The temperature sensor has a high temperature sensitivity of -207.8 pm/°C at 35-40 °C. Using cost-effective optical materials, we believe that this athermal design holds promise for overcoming the high temperature-dependent wavelength shift of photonic waveguide devices.