The Cargill-Type Rearrangement in Natural Product Synthesis

作者：Wen Xun, De‐Yun Ma, R.R. Chen, Shaobin Su, Bo Xu · 发表于：Synthesis · 年份：2025 · DOI：10.1055/a-2640-7480 · 被引用次数：1 · 研究领域：Microbial Natural Products and Biosynthesis、Chemical Synthesis and Analysis、Synthesis and Catalytic Reactions

Abstract Natural products are a prolific source of drug leads due to their unique architectures and potent bioactivity. However, their structural complexity often presents formidable challenges for total synthesis. Skeletal editing has recently emerged as a powerful strategy to streamline synthetic routes by selectively reorganizing molecular frameworks. In this context, the Cargill-type rearrangement offers a unique yet underutilized approach to skeletal editing via carbonyl migration. Despite its value, this transformation has not been systematically reviewed. Here, we provide the first focused summary of Cargill-type rearrangements in natural product synthesis, highlighting mechanistic insights and key examples to illustrate their synthetic potential.