CT-based deep learning radiomics analysis for preoperative Lauren classification in gastric cancer and explore the tumor microenvironment

作者：Ming Cheng, Yimin Guo, Huiping Zhao, Hanyue Zhang, Pan Liang, Jianbo Gao · 发表于：European Journal of Radiology Open · 年份：2025 · DOI：10.1016/j.ejro.2025.100667 · 被引用次数：7 · 研究领域：Ferroptosis and cancer prognosis、Gastric Cancer Management and Outcomes、Radiomics and Machine Learning in Medical Imaging

Purpose: This study aimed to investigate the usefulness of CT-based deep learning radiomics analysis (DLRA) for preoperatively differentiating Lauren classification in gastric cancer (GC) patients and explore the tumor microenvironment. Methods: 578 patients were recruited from January 2015 to June 2024, and divided into the training cohort (n = 311), the internal validation cohort (n = 132), and the external validation cohort (n = 135). Clinical characteristics were collected. Radiomics features were extracted from CT images at arterial phase (AP) and venous phase (VP). A radiomics nomogram incorporating radiomics signature and clinical information was built for distinguishing Lauren classification, and its discrimination, calibration, and clinical usefulness were evaluated. RNA sequencing data from The Cancer Imaging Archive database were used to perform transcriptomics analysis. Results: The nomogram incorporating the two radiomics signatures and clinical characteristics exhibited good discrimination of Lauren classification on all cohorts [overall C-indexes 0.815 (95 % CI: 0.739-0.869) in the training cohort, 0.785 (95 % CI: 0.702-0.834) in the internal validation cohort, 0.756 (95 % CI: 0.685-0.816) in the external validation cohort]. It outperformed the clinical model in predictive ability. The calibration and decision curve substantiated the model's excellent fitness and clinical applicability. Further, transcriptomics analysis showed that the differentially expressed ...